Scripps Translational Science Institute

In this section

Capabilities and Core Functions

STSI drives the integration of genomics into the realm of personalized medicine by providing key services via our Core Laboratories, by supporting the Scripps Genomic Medicine projects, by leading the Scripps Genomic Health Initiative, and by initiating with partners in industry, academia, and health to improve patient access to the best medical research available.

1. Targeted DNA Sequencing Using State of the Art Next Generation Technology

Illumina Genome Analyzer IIx (GAIIx)

Life Technologies Solid3 (SOLiD3)

2. High Throughput Genotyping

Sequenom MassArray iPLEX genotyping (custom content: 1-25 SNPs)

Illumina Goldengate genotyping (384-1536 SNPs) for fixed and custom content

Illumina Infinium whole-genome genotyping products, including:

Human660W-Quad beadchip kits
Human1M-Duo beadchip kits
HumanOmni-1 Quad beadchip kits
HumanCytoSNP-12 beadchip kits

3. Bioinformatics Support

Study design and power analysis

SNP selection for genotyping studies

Bioinformatics pipeline and variant calling for next-generation sequencing data

Association analysis of genome-wide association genotyping data

Association analysis of candidate gene SNP data

4. Clinical Trials Design

Support service available for all aspects of design and execution of randomized clinical trials, emphasizing individualized medicine

5. Science/Medicine Matchmaker

Bringing together basic scientists with clinical investigators to enhance understanding of a particular disease or condition and to foster close collaborations

6. ResearchMatch

A CTSA consortium initiative (coordinated via the Vanderbilt Institute for Clinical and Translational Research) to develop the first national, disease-neutral, centralized volunteer recruitment agency

Connecting individuals who wish to participate in research with eligible researchers nationwide